Physical Growth and Neurodevelopment of a Cohort of Children after 3.5 Years of Follow-up from Mothers with Zika Infection during Pregnancy—Third Report of the ZIKERNCOL Study

Abstract Introduction In utero Zika virus (ZIKV) exposure has been related to a group of congenital structural abnormalities called the syndrome, which also neurodevelopment alterations even in normocephalic children. Physical growth less explored, and delayed malnutrition have reported. Objective The objective this study is describe features infants born from cohort mothers with RT-PCR confirmed ZIKV during pregnancy Risaralda, Colombia. Methods We conducted retrospective cohort, including children infection was measured using WHO standards, abbreviated scale 2 validated for Results After verifying inclusion exclusion criteria, 16 were followed median time 28 months (IQR 23–31 months); total 116 visits, 87.5% (n = 14) patients developed alteration. Five presented post-natal microcephaly, among them, four or low height. Six macrocephaly. Patients normal head circumference had neurodevelopment. Only one patient microcephaly persisted impairment at end follow-up. All macrocephaly Discussion Our suggests that could be altered exposure. found high proportion overgrowth Future studies should consider endocrine follow-up explore these findings’ possible aetiologies. Conclusion alterations, particularly addition impairment, exposure, those without CZS.